Education Background
Medicine Postdoctoral Fellow - 2014 Northwestern University, Institute for BioNanotechnology
Neuroscience Ph.D - 2009 Indian Institute of Technology (in collaboration with Brain Science Institute, RIKEN, Japan)
Medical Science and Technology M.S - 2004 Indian Institute of Technology
M.B.B.S. - 2000 University of Calcutta
Courses Taught
- BY471 - Anatomy and Physiology I
- BY473 - Anatomy and Physiology I Laboratory
Research Interests
The biochemical and biophysical properties of cellular microenvironment send instructive signals to cells to control a variety of processes such as proliferation, migration, differentiation and apoptosis. Our lab aims for a molecular level understanding of these regulatory mechanisms using designed artificial matrices as a tool. In collaboration with experts from the field of chemistry and materials science, the matrices will be built on a modular, self-assembled materials platform to take advantage of the controllable nanostructure and mechanical properties these materials afford. In addition, such materials have the ability to present or release of bioactive molecules and incorporate dynamic properties such as stimuli-triggered spatio-temporal modulation in the material properties and bioactivity. We will focus on understanding how material properties such as stiffness, topography, alignment and surface charge affect the events at the cell-material interface (e.g. receptor mobility and clustering, cytoskeletal organization) and how these surface interactions lead to activation of signaling cascades and modulation of gene expression. We will also investigate the significance of temporal presentation of extracellular cues on cell development. Our long-term goal is to improve stem cell-based regenerative strategies where rationally designed materials could be used to drive transplanted cells into preferred cell lineage and function.
Publications
Publications (last 5 years)
* indicates equally contributing authors
- Saahir Khan, Shantanu Sur, Patricia Dankers, Ricardo Da Silva, Job Boekhoven, Taylor Poor, Samuel I. Stupp (2014): 鈥淧ost-assembly functionalization of supramolecular nanostructures with bioactive peptides and fluorescent proteins by native chemical ligation鈥, Bioconjugate Chemistry, Volume 25, Issue 4, 707-717.
- Shantanu Sur, Mustafa O. Guler, Matthew J.Webber, Eugene T. Pashuck, Masao Ito, Samuel I. Stupp, Thomas Launey (2014): 鈥淪ynergistic regulation of cerebellar Purkinje neuron development by laminin epitopes and collagen on an artificial hybrid matrix construct鈥, Biomaterials Science, Volume 2, Issue 6, 903-914
- Christina J. Newcomb*, Shantanu Sur*, Julia H. Ortony, One-Sun Lee, John B. Matson, Job Boekhoven, Jeong Min Yu, George C. Schatz, Samuel I. Stupp (2014): 鈥淐ell death versus cell survival instructed by supramolecular cohesion of nanostructures鈥, Nature Communications, Volume 5, 3321.
- Eric J. Berns*, Shantanu Sur*, Joshua E. Goldberger, Samuel I. Stupp (2014): 鈥淎ligned neurite outgrowth and directed migration in monodomain gels of self-assembling, peptide based nanofibers鈥, Biomaterials, Volume 35, Issue 1, 185-195.
- Job Boekhoven, Charles Perez Rubert, Shantanu Sur, Amanda Worthy, Samuel I. Stupp (2013): 鈥淒ynamic display of bioactivity via host guest chemistry鈥, Angewandte Chemie Int Ed English, Volume 52, Issue 46, 12077-12080.
- Shantanu Sur*, Christina J. Newcomb*, Matthew J. Webber, Samuel I. Stupp (2013): 鈥淭uning supramolecular mechanics to guide neuron development鈥, Biomaterials, Volume 34, Issue 20, 4749-4757.
- R. Helen Zha, Shantanu Sur, Samuel I. Stupp (2013): 鈥淪elf assembly of cytotoxic peptide amphiphiles into supramolecular membranes for cancer therapy鈥, Advanced Healthcare Materials, Volume 2, Issue 1, 126-133.
- Sungsoo S. Lee, Brian J. Huang, Stuart R. Kaltz, Shantanu Sur, Christina J. Newcomb, Stuart R. Stock, Ramille N. Shah, Samuel I. Stupp (2013): 鈥淏one regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds鈥, Biomaterials, Volume 34, Issue 2, 452-459.
- Shantanu Sur*, John B. Matson *, Matthew J.Webber, Christina J. Newcomb, Samuel I. Stupp (2012): 鈥淧hotodynamic control of bioactivity in a self-assembled matrix,鈥 ACS Nano, Volume 6, Issue 12, 10776-10785.
- Saahir Khan, Shantanu Sur, Christina J. Newcomb, Elizabeth A. Appelt, Samuel I. Stupp (2012): 鈥淪elf-Assembling glucagon-like peptide 1-mimetic peptide amphiphiles for enhanced activity and proliferation of insulin-secreting cells鈥, Acta Biomaterialia, Volume 8, Issue 5, 1685-1692.
- Shantanu Sur, Eugene Pashuck, Mustafa Guler, Masao Ito, Samuel I. Stupp, Thomas Launey (2012): 鈥淎 hybrid nanofiber matrix to control the survival and maturation of brain neurons鈥 Biomaterials, Volume 33, Issue 2, 545-555.